Key Moments

Elizabeth Iorns at Female Founders Conference 2014

Y CombinatorY Combinator
Science & Technology5 min read17 min video
Mar 12, 2014|2,855 views|23|1
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TL;DR

Founders of Science Exchange, a marketplace for scientific collaboration, discovered that solving their own research frustrations created a compelling founding story and an essential business model. The company faced initial resistance from the scientific community, highlighting the importance of persistence and focusing on core values.

Key Insights

1

Science Exchange, founded by a breast cancer researcher frustrated with outsourcing experiments, became a marketplace connecting researchers with over 800 labs globally.

2

Founders should solve their own problems as it provides a deep understanding, passion, and a compelling narrative for investors and employees.

3

It's as easy to solve a big problem as a small one; identifying a real need through user research and a minimum viable product (MVP) is crucial.

4

Building the right team requires individuals who not only possess diverse skills but also share the company's vision and values deeply.

5

Company culture, exemplified by Science Exchange's 'FORCE' values (Fearless, Open, Respectful, Curious, Entrepreneurial), is critical for team retention and overall success.

6

The company uses a quarterly planning meeting and bi-weekly sprint cycles with daily check-ins to maintain momentum and ensure action-oriented progress.

Solve your own problem for a stronger foundation

Dr. Elizabeth Iorns, a former academic breast cancer researcher, founded Science Exchange to address her own struggles with the inefficiency of outsourcing scientific experiments. She emphasizes Paul Graham's advice that founders should tackle problems they personally experience, as this fosters a deep understanding and passion for the solution. This personal connection provides a compelling narrative for raising capital, attracting press, and building a team, as potential investors and employees can connect with the founder's authentic motivation. The scientific research landscape had changed, making it impossible to conduct all necessary experiments within a single lab; Science Exchange was born from this realization to create an online marketplace that addresses both the infrastructural and incentive system barriers hindering effective scientific collaboration.

Address significant challenges

It is as difficult to found a company that solves a minor issue as it is to solve a major one, so it's more strategic to focus on substantial problems. Aaron Puzder, founder of Mint, highlighted that serving a 'real need' differentiated his startup from many others. To validate a problem's significance, founders should engage with potential users early on through market research, understanding the current solutions (the status quo), and assessing market size and competitive landscapes. Launching a minimal viable product (MVP) quickly is essential for gathering real-time feedback and confirming that the proposed solution effectively addresses the identified problem.

Assemble a dedicated and diverse team

A successful company requires a team that not only possesses strong skills but also shares the founder's vision and passion. Scott Hyman, co-founder of Meetup, noted the importance of a team that cares about the endeavor as much as the founder does. Iorns advises diversifying your network by connecting with individuals outside your immediate field, as people from similar backgrounds may not bring the necessary range of skills for building a startup. Attending entrepreneurial events and utilizing online platforms can help in finding individuals with complementary skill sets who are also passionate about the company's mission.

Cultivate a strong company culture

Company culture is a critical, though often overlooked, element for building and retaining a great team, and for ensuring the founder actually enjoys working at their own company. Science Exchange established core values encapsulated by the acronym FORCE: Fearless, Open, Respectful, Curious, and Entrepreneurial. These values are reinforced through regular activities, such as monthly awards for team members who embody them. Clearly defining these values from the outset and ensuring that all team members and partners, including advisors and investors, align with them is paramount.

Select partners who align with your vision

Investors should be viewed as more than just a source of capital; they can be invaluable assets if they believe in the company's vision and share its values. The adage 'investors are employees you can never fire' underscores the importance of careful selection. Science Exchange benefited immensely from advisors like Andy Weismann of Union Square Ventures, who not only provided financial support and strategic advice but also deeply shared the company's values, contributing to its growth.

Prioritize execution and focus with agility

Rapid progress and demonstrated traction are crucial in the fast-paced startup environment to avoid failure. The company employs a quarterly planning cycle to set goals and an agile framework with two-week sprints for both product and business teams. This involves daily check-ins to discuss progress and address any roadblocks, fostering openness, team awareness, and momentum. This structured approach helps ensure that efforts are focused on actionable items that drive company growth, rather than trying to build every component in-house. For instance, Science Exchange leverages external services for non-core functions like payment processing and hosting, allowing them to concentrate on their unique marketplace offering.

Invest in early users and essential relationships

Doing things that don't scale, as exemplified by Airbnb founders taking photos of listings, is vital for learning and establishing a unique value proposition. For Science Exchange, this translated into building deep relationships with their first 1,000 users and rigorously vetting their network of over 800 labs. This focus on high-quality, verified labs and exceptional customer support—an area often lacking in the scientific community—became a significant competitive advantage, creating a foundation for future growth and customer loyalty. This approach ensures the product resonates deeply with its initial user base, paving the way for broader adoption.

Persistence is key to overcoming obstacles

Startups typically fail due to running out of money or giving up. Steve Jobs' advice to not lose faith when life hits hard is particularly relevant. Science Exchange faced initial adversity when their platform was initially perceived by the scientific community as 'the eBay for science,' suggesting an outsider's imposition rather than a collaborative tool. Overcoming this required considerable persistence to demonstrate their own scientific background and commitment to improving research efficiency and quality. These efforts were instrumental in building the trusted lab relationships that form the core of their competitive advantage.

9 Lessons for Startup Founders

Practical takeaways from this episode

Do This

Solve a problem that affects you personally.
Address a real, significant problem in the market.
Build a team that shares your vision and passion.
Focus on establishing a strong company culture from the start.
Select advisors and investors who align with your values.
Be action-oriented and move quickly to show traction.
Prioritize core activities; leverage external services for non-core functions.
Do things that don't scale, especially with early users and customer support.
Be persistent and don't give up when facing challenges.

Avoid This

Don't try to solve a small problem when a big one exists.
Don't just solve a problem for yourself; validate it with potential users.
Don't assume just having skilled people is enough; shared vision is crucial.
Don't neglect company culture, as it impacts team building and retention.
Don't pick investors solely based on funding; their alignment is key.
Don't get bogged down in non-essential tasks; focus on what drives growth.
Don't solely rely on scaling methods from the beginning; early customer relationships matter.
Don't give up when faced with setbacks or negative perceptions.

Common Questions

Science Exchange is a marketplace for scientific collaboration where researchers can order experiments from labs worldwide. It addresses the difficulty researchers face in conducting all necessary experiments within a single lab and aims to improve efficiency and access to technical expertise.

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