What are the signs of low nitric oxide levels?

The earliest sign is often erectile dysfunction. Other symptoms include high blood pressure, exercise intolerance (inability to exercise moderately for 15-30 minutes), diabetes, and cognitive impairment. In essence, poor cardiovascular and metabolic health can indicate low nitric oxide.

How does aging affect nitric oxide production?

With age, there is a natural decline in nitric oxide production, typically starting around age 30. Population studies show a 10-12% decline per decade in endothelial function, which is directly related to nitric oxide synthesis.

Can nitric oxide deficiency lead to Alzheimer's disease?

Yes, Alzheimer's is considered a vascular disease. Nitric oxide deficiency can lead to reduced blood flow to the brain, impaired glucose uptake, inflammation, and oxidative stress, all of which are mechanisms involved in Alzheimer's development.

Why is the medical industry resistant to promoting nitric oxide?

The healthcare system is largely a business focusing on managing symptoms with drugs rather than addressing root causes like nitric oxide deficiency. Pharmaceutical companies influence research and policy, making treatments that don't involve long-term medication less profitable.

How does the oral microbiome contribute to nitric oxide production?

Specific bacteria in the mouth possess the nitrate-reducing enzyme necessary to convert dietary nitrates into nitrites and then nitric oxide. Using antiseptic mouthwash or fluoride toothpaste kills these beneficial bacteria, disrupting this vital process.

What are the dangers of using fluoride in toothpaste and mouthwash?

Fluoride is a known toxicant that has no benefit and significant risks. It can lower IQ in children, impair thyroid function, and is a neurotoxin. Furthermore, it kills the beneficial bacteria in the oral microbiome needed for nitric oxide production.

Are antacids and proton pump inhibitors (PPIs) harmful?

Yes, suppressing stomach acid production with antacids or PPIs is damaging. Stomach acid is crucial for protein breakdown and the absorption of many essential nutrients. Inhibiting it leads to nutrient deficiencies like magnesium and iodine.

How does nasal breathing relate to nitric oxide?

Nasal breathing stimulates the enzyme that produces nitric oxide in the upper airways. This nitric oxide is then delivered to the lungs, dilating bronchioles and pulmonary arteries, improving oxygen uptake and lowering blood pressure.

What foods should I eat to increase nitric oxide?

While some foods like beets are known for their nitrate content, the key is what NOT to eat. You must avoid sugar and high-glycemic foods. A balanced diet with quality protein and fats, and minimal carbs, is recommended. However, the presence of healthy oral bacteria is essential for dietary nitrates to be converted into nitric oxide.

Can you have too much nitric oxide?

Yes, excessive nitric oxide can be dangerous. The primary risks are an unsafe drop in blood pressure (leading to lightheadedness or fainting) and methemoglobinemia, which impairs oxygen transport. Dose dictates poison.

How is nitric oxide related to longevity?

Nitric oxide is considered a foundational longevity molecule because it supports stem cell mobilization, activates telomerase to prevent telomere shortening, and helps maintain mitochondrial function – all key hallmarks of aging and health span.

No.1 Nitric Oxide Expert: This is the anti-aging cure no one is talking about!

The Diary Of A CEO

People & Blogs4 min read87 min video

Apr 14, 2025|3,322,235 views|141,453|8,688

The Diary Of A CEO steven bartlett steve bartlett podcast the diary of a CEO podcast life lessons CEO

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Key Moments

TL;DR

Nitric oxide is key to health & aging. Its decline impacts blood flow, leading to chronic diseases. Restoring it is vital.

Key Insights

Nitric oxide (NO) is a crucial signaling molecule regulating blood flow, oxygen delivery, and stem cell mobilization in the body.

A decline in NO production with age is the earliest indicator of age-related chronic diseases like Alzheimer's, diabetes, and cardiovascular disease.

Symptoms of NO deficiency include erectile dysfunction, high blood pressure, exercise intolerance, and cognitive impairment.

Factors like certain mouthwashes, fluoride, sugar, and poor oral hygiene disrupt NO production by damaging the oral microbiome.

Optimizing NO levels is linked to longevity through improved stem cell function, telomere maintenance, and mitochondrial health.

Lifestyle changes such as avoiding sugar, maintaining oral hygiene with non-fluoridated toothpaste, nasal breathing, and moderate exercise can help preserve NO levels.

NITRIC OXIDE: THE FOUNDATIONAL MOLECULE

Nitric oxide (NO) is a vital signaling molecule naturally produced in the body, primarily within the endothelium lining blood vessels. It plays a critical role in regulating blood flow, ensuring adequate oxygen delivery to tissues, and mobilizing stem cells for repair and regeneration. As we age, our natural production of nitric oxide declines, which Dr. Nathan Bryan identifies as the earliest event triggering age-related chronic diseases. Understanding and optimizing nitric oxide levels is presented as a cornerstone for preventing these conditions and promoting longevity.

COLLATERAL DAMAGE FROM NITRIC OXIDE DECLINE

The diminishing production of nitric oxide has far-reaching consequences for health. Early signs often manifest as erectile dysfunction in both men and women, due to impaired blood vessel dilation. As the deficiency progresses, it leads to increased blood pressure (hypertension), as blood vessels become constricted. This lack of dilation also contributes to conditions like diabetes, by impairing insulin signaling, and exercise intolerance, where even moderate physical activity becomes difficult. Furthermore, reduced blood flow to the brain is implicated in cognitive decline and diseases like Alzheimer's, underscoring the systemic impact of NO deficiency.

THE ORAL MICROBIOME: A CRITICAL PARTNER

A significant factor influencing nitric oxide production is the health of the oral microbiome. Certain bacteria in the mouth are essential for converting dietary nitrates into nitrites, and subsequently into nitric oxide. Practices like using antiseptic mouthwashes, fluoride toothpaste, and even regular exposure to fluoride in water can decimate these beneficial bacteria. This disruption not only impairs NO synthesis from dietary sources but has been directly linked to increased blood pressure. Maintaining a balanced oral microbiome through avoiding harsh chemicals and supporting beneficial bacteria is crucial for systemic health.

LONGEVITY AND AGE-RELATED DISEASE PREVENTION

Dr. Bryan posits that nitric oxide is fundamental to longevity by addressing three key hallmarks of aging. Firstly, it stimulates the mobilization and differentiation of stem cells, crucial for repair. Secondly, it activates telomerase, an enzyme that prevents the shortening of telomeres, which are protective caps on our chromosomes associated with lifespan. Thirdly, nitric oxide promotes mitochondrial function, enhancing cellular energy production. By optimizing nitric oxide, we combat the cellular senescence, telomere shortening, and mitochondrial dysfunction that drive age-related diseases, thereby extending healthspan.

LIFESTYLE CHOICES THAT IMPACT NITRIC OXIDE

Several lifestyle choices directly influence nitric oxide levels. Avoiding sugar and high-glycemic foods is paramount, as sugar can 'gum up' the enzymes responsible for NO production and harm the oral microbiome. Conversely, dietary habits that support NO production involve consuming nitrate-rich foods like leafy greens and ensuring the presence of beneficial oral bacteria to process them. Other beneficial practices include deep nasal breathing (which activates NO production in the airways), moderate exercise, and adequate sun exposure. Conversely, practices like mouth breathing and using fluoride-laden dental products actively hinder NO synthesis.

THE PHARMACEUTICAL INDUSTRY AND HEALTH OUTCOMES

The conversation highlights potential conflicts within the healthcare system, where the business model may prioritize managing symptoms with medication rather than addressing root causes. Dr. Bryan suggests that the trillions of dollars in the pharmaceutical industry can influence research and policy, sometimes at the expense of public health. He points to the fact that the US, despite high healthcare spending, ranks poorly in health outcomes. This systemic issue can hinder the adoption of nitric oxide as a primary therapeutic strategy, as it might reduce reliance on long-term medications, impacting the industry's financial interests.

RESTORING NITRIC OXIDE: PATHWAYS AND STRATEGIES

Strategies to boost nitric oxide production are multifaceted. They begin with eliminating detrimental habits, such as the use of fluoride toothpaste and antiseptic mouthwashes, and reducing sugar intake. Prioritizing nasal breathing over mouth breathing and engaging in regular, moderate exercise are also key. For dietary intake, focusing on nitrate-rich vegetables and ensuring a healthy gut and oral microbiome is crucial, as these are the primary converters of dietary nitrate. Light therapy, particularly red and infrared light, and humming are also mentioned as ways to stimulate enzyme activity related to NO production.

THE INTERCONNECTEDNESS OF ORAL HEALTH AND SYSTEMIC DISEASE

The link between oral health and the rest of the body is profound and often underestimated. Poor oral hygiene, dental infections, and root canals can create reservoirs of bacteria that translocate into the bloodstream, contributing to systemic inflammation. This inflammation is implicated in diseases ranging from cardiovascular issues to certain cancers. The presence of specific bacteria in the mouth has been linked to increased risks of head and neck cancers, highlighting the importance of comprehensive oral care not just for dental health, but for overall well-being and disease prevention.

Mentioned in This Episode

●Products

●Books

●Concepts

●People Referenced

Improving Nitric Oxide Levels: Do's and Don'ts

Practical takeaways from this episode

Do This

Prioritize nasal breathing and deep breathing exercises.

Consider tongue scraping for a healthier oral microbiome.

Use non-fluoridated toothpaste.

Engage in moderate physical exercise (20-30 minutes daily).

Get 20-30 minutes of sunlight exposure daily.

Consider light therapy (red light beds, infrared saunas).

Eat a balanced diet with good quality protein and fats, low in carbs.

Maintain optimal sex hormone levels (testosterone for men, estrogen for women).

Consider Vitamin D supplementation if deficient.

Avoid This

Avoid sugar and high glycemic index foods, as they increase blood glucose and inhibit nitric oxide production.

Avoid antiseptic mouthwashes, antibacterial soaps, and fluoride rinses.

Do not use fluoride in toothpaste or drinking water.

Avoid antacids and proton pump inhibitors (PPIs) that suppress stomach acid.

Avoid products with aluminum.

Avoid mouth breathing; if severe, consult a dentist for airway assessment.

Do not neglect oral hygiene, as it's crucial for nitric oxide production.

Be cautious with biohacker advice; check credentials.

Common Questions

Nitric oxide is a naturally produced molecule in the body that acts as a signaling molecule. It's vital for regulating blood flow, oxygen delivery, and stem cell mobilization. Loss of nitric oxide production is an early indicator of age-related chronic diseases.

Topics

Erectile Dysfunction Oral Microbiome Mitochondrial Function Telomeres Stem Cells Health System Critique Breathing Techniques

Mentioned in this video

concepthigh blood pressure

A major driver of cardiovascular disease, often stemming from nitric oxide deficiency where blood vessels constrict due to an inability to dilate.

conceptoral microbiome

Plays a crucial role in nitric oxide production. Antiseptic toothpaste and mouthwash can kill beneficial bacteria, negatively impacting nitric oxide levels and overall health.

personLou Ignarro

A Nobel Prize winner for the discovery of nitric oxide, whose statement about restoring nitric oxide production changing medicine inspired Dr. Brian.

concepterectile dysfunction

Identified as the earliest sign of nitric oxide deficiency, affecting both men and women due to the inability of blood vessels to dilate.

conceptfluoride

Discussed as a toxicant detrimental to health; it has no proven benefit, lowers IQ in children, shuts down thyroid function, and is a neurotoxin. It's found in most toothpastes and municipal water.

conceptdiabetes

Linked to nitric oxide deficiency, as nitric oxide production is necessary for insulin signaling, and its loss leads to insulin resistance.

conceptcardiovascular disease

The leading cause of death worldwide, strongly linked to high blood pressure, which is often a consequence of nitric oxide deficiency.

conceptnitrous oxide

Distinguished from nitric oxide (NO), it's known as laughing gas and used as a dental anesthetic (N2O), a completely different substance.

productNexium

An over-the-counter proton pump inhibitor (PPI) that suppresses stomach acid production, leading to nutrient deficiencies.

personPatrick McKeown

Mentioned as a proponent of breathwork and nitric oxide benefits, who appeared on Dragon's Den.

bookThe Secret of Nitric Oxide

Dr. Nathan Brian's book, which educates consumers on nitric oxide, its importance, and how to prevent its age-related decline. It also chronicles his journey.

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