Metformin

How Our Hormones Control Our Hunger, Eating & Satiety

Andrew Huberman

A prescription drug developed for diabetes treatment, it potently reduces blood glucose by changing mitochondrial action in the liver via the AMPK pathway and increasing insulin sensitivity. Requires caution due to hypoglycemia risk.

Dr. Peter Attia, MD — Fasting, Metformin, Athletic Performance, and More | The Tim Ferriss Show

Tim Ferriss

A drug Peter Attia had previously viewed as a low-risk cancer-mitigating and longevity agent, but has changed his mind on for very healthy individuals due to its impact on mitochondrial performance.

Q&A With Tim — On Wealth, Legacy, Grief, Lyme Disease, and More | The Tim Ferriss Show

Tim Ferriss

A medication Tim Ferriss has experimented with in the past for anti-aging purposes, but not recently.

AMA #3: supplements, women’s health, patient care, and more (EP.26) | The Peter Attia Drive

Peter Attia MD

A pharmacological agent that acts as an AMPK activator, which Peter Attia prefers over berberine for its consistency and regulatory oversight.

222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D.

Peter Attia MD

A drug mentioned as a geroprotective molecule.

E26: State of Venture Capital, plus fan questions on longevity, decentralization & quantum computing

All-In Podcast

A medication mentioned as a compound that can mimic fasting on a cellular level and is used preventatively for longevity.

How to Ask Better Questions, Take Better Risks, and More! | The Tim Ferriss Show (Podcast)

Tim Ferriss

A medication that Tim Ferriss does not currently use but might incorporate in the future for longevity/autophagy protocols.

"Anti-Aging" Drugs — NAD, metformin, & rapamycin | The Peter Attia Drive Podcast (Ep 207, AMA 35)

Peter Attia MD

A geroprotective molecule discussed as a primary topic.

202 - Peter on nutrition, disease prevention, and more — looking back on the last 100 episodes

Peter Attia MD

A drug that will be discussed in a future AMA episode with Matt Kaeberlein regarding its role in longevity alongside Rapamycin and NAD+ precursors.

Outlive: The Science and Art of Longevity — Dr. Peter Attia

Tim Ferriss

Mentioned as a drug that can be important for longevity, alongside rapamycin and APO B control.

Female Hormone Health, PCOS, Endometriosis, Fertility & Breast Cancer | Dr. Thaïs Aliabadi

Andrew Huberman

DOGE vs USAID, Crypto Framework, Google's $75B AI Spend, US Sovereign Wealth Fund, GLP-1s

All-In Podcast

A common drug for type 2 diabetes, suggested as part of a simple health protocol.

Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis

FoundMyFitness

A drug discussed as a potential anti-aging candidate due to its activation of certain signaling pathways, though its long-term safety in healthy individuals is questioned.

Supplements for Longevity & Their Efficacy | Dr. Peter Attia

Andrew Huberman

A drug mentioned as a potential longevity intervention, but noted by Attia to have failed in ITP studies for lifespan extension.

Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent [AMA 45 sneak peek]

Peter Attia MD

A drug primarily used for type 2 diabetes that acts to reduce glucose production by the liver, also discussed for its geroprotective effects.

216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.

Peter Attia MD

A widely used medication that likely works mainly by slowing the conversion of NADH back to NAD+ by inhibiting complex I of the electron transport chain, primarily in the liver.

Coaching Cues, Fat-Free Mass Index, Non-Responders, and Dr. Brad Dieter (Podcast Episode 10)

Stronger By Science

Medication used for blood sugar control, mentioned in the context of standard care for diabetes, affecting the perceived benefit of new dietary interventions.

204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D.

Peter Attia MD

A drug commonly used for type 2 diabetes, now being studied for its potential geroprotective effects, stemming from observations of lower mortality and disease rates in diabetics taking it.

201 - Deep dive back into Zone 2 Training | Iñigo San-Millán, Ph.D. & Peter Attia, M.D.

Peter Attia MD

A medication that inhibits complex one of the electron transport chain, a key component of mitochondrial function. Its effect on lactate levels makes interpreting Zone 2 data challenging in patients taking it, especially when considering its use as a geroprotective agent.

Dr. Rhonda Patrick Returns | The Tim Ferriss Show (Podcast)

Tim Ferriss

A biguanide derivative primarily used for type 2 diabetes, controlling blood glucose and restoring insulin sensitivity. Research suggests it may prevent age-related diseases and extend lifespan by inhibiting mitochondrial complex one, but its long-term effects on healthspan are still being studied.

Dom D'Agostino Returns (Full Episode) | The Tim Ferriss Show (Podcast)

Tim Ferriss

A drug being studied for its potential effects on aging, gene expression, and longevity, with ongoing trials like the MILE study. It may mimic calorie restriction effects and elevate ketones.

Shay Carl Interview (Full Episode) | The Tim Ferriss Show (Podcast)

Tim Ferriss

A drug mentioned by Tim Ferriss in the context of extending life and the pursuit of immortality.

Patrick Arnold Interview (Full Episode) | The Tim Ferriss Show (Podcast)

Tim Ferriss

A drug mentioned as a potential anti-aging compound, with promising research data, though Patrick Arnold sometimes experiences stomach upset from it.

E110: 2023 Bestie Predictions!

All-In Podcast

Mentioned for its incredible benefits in cell regeneration, longevity, and glucose management, even when taken prophylactically, especially given the prevalence of pre-diabetes in the American diet.