Metformin
Named as one of the drugs under study or use in longevity research to mimic calorie-restriction effects.
Research
Common Themes
Videos Mentioning Metformin
The Biology of Slowing & Reversing Aging | Dr. David Sinclair
Andrew Huberman
A prescription drug for type 2 diabetics that mimics low energy, found in epidemiological data to be associated with longer lifespan and protection against age-related diseases. Needs to be timed around exercise.
Developing a Rational Approach to Supplementation for Health & Performance | Huberman Lab Podcast
Andrew Huberman
A prescription drug that can reduce blood glucose, indirectly affecting sex hormone binding globulin and free testosterone levels.
#87—Rick Johnson, MD: Fructose—the common link in hypertension, insulin resistance, T2D, & obesity?
Peter Attia MD
A drug used to treat diabetes, which works by stimulating the AMPK pathway.
#35 – Nir Barzilai, M.D.: How to tame aging
Peter Attia MD
A pharmaceutical drug, initially for Type 2 diabetes, now being studied by Dr. Barzilai for its anti-aging properties in the TAME trial.
#31 – Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease
Peter Attia MD
A commonly used anti-diabetic drug, discussed for its role in longevity, cancer, and inflammation, believed to be a weak mitochondrial complex one inhibitor.
#27 – David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging
Peter Attia MD
A widely used anti-diabetic drug that also impacts longevity pathways, often taken by David Sinclair and his colleagues in low doses due to its additive effects with other longevity molecules.
Effects of Fasting & Time Restricted Eating on Fat Loss & Health | Huberman Lab Podcast #41
Andrew Huberman
A prescription drug used as a glucose disposal agent that leads to dramatic reductions in blood glucose, mimicking fasting. Caution is advised due to potential side effects like hypoglycemia.
Vitalik Buterin — Creator of Ethereum feat. Naval Ravikant
Tim Ferriss
A drug used in the treatment of type 2 diabetes (glucophage) that Vitalik Buterin takes, also discussed in the context of life extension.
The Science of Eating for Health, Fat Loss & Lean Muscle | Dr. Layne Norton
Andrew Huberman
A medication sometimes discussed as a glucose scavenger, but its role in general health and longevity is complex and requires careful consideration.
#71 – Katherine Eban: Widespread fraud in the generic drug industry
Peter Attia MD
A drug commonly prescribed for diabetes, whose generic extended-release versions are often reported by patients as being less effective or causing more gastrointestinal side effects than the branded Glucophage XR.
The Science & Practice of Perfecting Your Sleep | Dr. Matt Walker
Andrew Huberman
Drug mentioned in the context of diabetes management, compared to the fundamental importance of exercise and sleep for health.
#18 – Richard Isaacson, M.D.: Alzheimer’s prevention
Peter Attia MD
Discussed in the context of breast cancer risk reduction and as an analogy for dietary choices impacting disease risk, raising questions about prevention and patient blame.
#70–David Sinclair, PhD: How cellular reprogramming could slow our aging clock, & the latest on NAD
Peter Attia MD
A drug that inhibits mitochondria to stimulate their growth, with recent studies suggesting it may blunt exercise effects in metabolically healthy individuals, leading to a suggestion of pulsed dosing.
#66 – Vamsi Mootha, MD: Aging, T2D, cancer, dementia, Parkinson’s—do all roads lead to mitochondria?
Peter Attia MD
A drug that activates AMPK and inhibits mitochondrial complex I, leading to a homeostatic response that may contribute to its benefits in type 2 diabetes and potential longevity effects.
#10 – Matt Kaeberlein, Ph.D.: rapamycin and dogs — living longer, healthier & turning back the clock
Peter Attia MD
A drug considered very safe with good human data suggesting it reduces age-related diseases, proposed for the TAME trial as an intervention for healthy aging.
How to Lose Fat with Science-Based Tools
Andrew Huberman
A prescription drug used to reduce blood glucose and lower insulin levels, thereby increasing fat oxidation.
David Sinclair: Extending the Human Lifespan Beyond 100 Years | Lex Fridman Podcast #189
Lex Fridman
A diabetes drug taken by David Sinclair, which in combination with lifestyle changes, is expected to help extend human lifespan beyond 100 years.
The Random Show — Blockchain/Crypto Investing, NFT Experiments, Dogecoin, Zen Buddhism, and More
Tim Ferriss
A common drug for type 2 diabetes, with unclear health benefits for non-diabetics.
Juan Carlos Izpisua Belmonte, Altos Labs | All-In Summit 2024
All-In Podcast
A molecule used by diabetic people to lower glucose, which has also shown potential to reprogram cells and increase lifespan in monkeys.
How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett
Andrew Huberman
A medication that can help with insulin sensitization, sometimes useful for women with PCOS who have significant insulin resistance.
Controlling Sugar Cravings & Metabolism with Science-Based Tools | Huberman Lab Podcast #64
Andrew Huberman
A prescription drug used to reduce blood glucose, mentioned as being on par with Berberine in potency.
#49–Matt Walker, Ph.D., on Sleep (Part 3 of 3): Effects of poor sleep on metabolism & performance...
Peter Attia MD
A drug prescribed for pre-diabetic states, which lack of sleep can make a healthy individual appear to need.
#05 - Dom D’Agostino, Ph.D.: ketosis, n=1, exogenous ketones, HBOT, seizures, and cancer
Peter Attia MD
A drug used in many studies in D'Agostino's lab for its effects on glucose levels, insulin, and amp-kinase activation, inhibiting gluconeogenesis and mildly inhibiting mitochondria complex I, and is also considered a cheap drug for glucose ketone index maintenance in cancer.
#02 – Rhonda Patrick, Ph.D.: paradox of IGF-1, ketogenic diets and genetics, benefits of sauna, NAD+
Peter Attia MD
A common diabetes medication, discussed for its effects on glucose reduction and its potential inhibition of mitochondrial complex one, leading to questions about its NAD+ effects.