Metformin

Jamie Metzl on The Portal (with host Eric Weinstein) Ep. #029 – The Bio-Hacker will see you now

Eric Weinstein

Named as one of the drugs under study or use in longevity research to mimic calorie-restriction effects.

#140 - Gerald Shulman, MD, PhD: Insulin resistance—molecular mechanisms and clinical implications

Peter Attia MD

A common drug for type 2 diabetes, discussed for its mechanisms of action, particularly its effect on gluconeogenesis and mitochondrial redox state, not complex I inhibition at clinical doses.

#48–Matt Walker, Ph.D., on Sleep (Part 2 of 3): Heart disease, cancer, causes of sleep disruption...

Peter Attia MD

A powerful drug discussed in the context of weight loss, but the host argues that an exceptional diet is far more potent than the drug for metabolic health.

AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory

Andrew Huberman

A drug discussed for its potential to lower blood glucose and impact mTOR, but not taken by Huberman due to insufficient lifespan data and potential side effects.

#41–Jake Kushner, M.D.: How to thrive with T1D and the valuable insights that can benefit anyone

Peter Attia MD

A drug that lowers glucose by activating AMPK, used in Type 2 Diabetes, mentioned for its effect on glucose disposal and the potential for lower insulin levels.

#134 - James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise

Peter Attia MD

A diabetes medication mentioned for its historical garnering of longevity attention, but with potential concerns for efficacy in very healthy, high-exercising individuals.

175 - The biology of aging, rapamycin, and other interventions that target the aging process

Peter Attia MD

A drug considered for the TAME trial due to existing human data supporting its use in targeting aging, despite concerns about regulatory appetite for rapamycin.

171- Longevity science: caloric restriction studies, aging biomarkers & possible longevity molecules

Peter Attia MD

An FDA-approved drug identified as having the most potential for geroprotection based on human data, despite weak mouse data.

Journal Club with Dr. Peter Attia | Metformin for Longevity & The Power of Belief Effects

Andrew Huberman

A drug used for over 50 years to treat type 2 diabetes, known to inhibit complex one of the mitochondria and reduce hepatic glucose output. Its geroprotective effects are debated.

The Potential of Metabolic Psychiatry — Chris Palmer, MD

Tim Ferriss

A medication predominantly used for type 2 diabetes, which appears to impair mitochondrial function in some people and can reduce the benefits of exercise, highlighting the caution against its use for life extension in metabolically healthy individuals.

#123–Joan Mannick & Nir Barzilai: Rapamycin and metformin—longevity, immune enhancement, & COVID-19

Peter Attia MD

An early-line treatment for type 2 diabetes, now extensively studied for its potential longevity and immune-enhancing properties.

Health & Longevity: A Conversation with Peter Attia (Episode #328)

Sam Harris

A drug mentioned in the context of longevity research and potential future discussions.

John Abramson: Big Pharma | Lex Fridman Podcast #263

Lex Fridman

A diabetes drug costing about four dollars a month, compared to Trulicity, and shown in the Diabetes Prevention Program study to be less effective than lifestyle changes for preventing diabetes.

#118 – Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging

Peter Attia MD

A drug that is excellent for diabetics and has shown retrospective data of longevity in treated diabetics, but its benefit in perfectly healthy individuals is questioned due to its potential adverse effects on mitochondrial function.

Q&A on Zone 2 Exercise with Peter Attia, M.D.

Peter Attia MD

A medication that Peter Attia states categorically lowers Zone 2 thresholds in patients, potentially by inhibiting mitochondrial complex 1.

#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

Peter Attia MD

A drug that mimics fasting by activating AMPK, potentially inducing autophagy. It has not been tested in autophagy-deficient mice.

Dr. Ben Bikman: How To Reverse Insulin Resistance Through Diet, Exercise, & Sleep

FoundMyFitness

Dr. Peter Attia — Longevity Drugs, Alzheimer's Disease, and More

Tim Ferriss

A drug with human data suggesting protective effects, particularly in people with diabetes, but did not extend life in mice when given alone in the ITP.

The Life-Extension Episode With Dr. Matt Kaeberlein | The Tim Ferriss Show

Tim Ferriss

The most commonly prescribed anti-diabetic drug, heavily discussed for its potential longevity effects, and the subject of the TAME human clinical trial.

The Science of Healthy Hair, Hair Loss and How to Regrow Hair

Andrew Huberman

A prescription drug that effectively improves insulin sensitivity, similar to berberine, by dramatically reducing blood sugar levels.

#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the ITP

Peter Attia MD

A diabetes drug that, despite epidemiological evidence for longevity benefits in diabetic humans, has largely failed to extend lifespan in ITP mice when tested alone.

Control Stress for Healthy Eating, Metabolism & Aging | Dr. Elissa Epel

Andrew Huberman

A drug mentioned in the context of managing metabolic health, against which diet is emphasized as a more profound solution for public health.

#103 – Looking back on the first 99 episodes: Strong Convictions, Loosely Held

Peter Attia MD

A drug initially taken by Peter Atia for its potential longevity and cancer benefits, but later re-evaluated due to concerns about mitochondrial toxicity and elevated lactate levels.

#37 – Zubin Damania, M.D.: Revolutionizing healthcare one hilariously inspiring video at a time

Peter Attia MD

A medication primarily used for type 2 diabetes, discussed for its potential to mimic caloric restriction and promote longevity by activating AMP kinase.