Rapamycin
Mentioned as a candidate drug for extending healthspan, part of the longevity interventions Jamie discusses.
Common Themes
Videos Mentioning Rapamycin
Jamie Metzl on The Portal (with host Eric Weinstein) Ep. #029 – The Bio-Hacker will see you now
Eric Weinstein
Mentioned as a candidate drug for extending healthspan, part of the longevity interventions Jamie discusses.
AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory
Andrew Huberman
A drug investigated for its ability to extend lifespan, targeting the mTOR pathway. Huberman does not currently take it due to data insufficiency for lifespan extension and potential side effects.
175 - The biology of aging, rapamycin, and other interventions that target the aging process
Peter Attia MD
A drug that inhibits the mTOR pathway, extensively discussed for its role in aging, immune function, and lifespan extension in laboratory animals. Its potential in humans is explored regarding dosing strategies and side effects.
171- Longevity science: caloric restriction studies, aging biomarkers & possible longevity molecules
Peter Attia MD
An FDA-approved drug identified as having the most potential for geroprotection based on mouse data, especially in sex-specific and dose-dependent ways.
Journal Club with Dr. Peter Attia | Metformin for Longevity & The Power of Belief Effects
Andrew Huberman
A drug that has consistently shown lifespan extension in male mice in the ITP, even when given late in life. It is an mTOR inhibitor.
The Potential of Metabolic Psychiatry — Chris Palmer, MD
Tim Ferriss
An immunosuppressant drug mentioned for its interesting life extension properties observed in various species and animal models, used as an example of a 'red hot variable' drug requiring caution and extensive research before repurposing.
#123–Joan Mannick & Nir Barzilai: Rapamycin and metformin—longevity, immune enhancement, & COVID-19
Peter Attia MD
A drug that inhibits mTOR, with initial clinical use as an immunosuppressant for transplant patients, now being studied for longevity and immune enhancement.
Health & Longevity: A Conversation with Peter Attia (Episode #328)
Sam Harris
An esoteric drug mentioned in the context of longevity research and potential future discussions.
#118 – Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging
Peter Attia MD
A compound originally identified on Easter Island and a key focus of the discussion, known for its ability to inhibit mTOR and its potential longevity effects, distinct from its immunosuppressive uses.
#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies
Peter Attia MD
A potent inhibitor of mTOR, which signals autophagy, and has demonstrated longevity benefits across all four models of eukaryotic cells. Its neuroprotective effects are being explored.
Q&A on Zone 2 Exercise with Peter Attia, M.D.
Peter Attia MD
Peter Attia expresses positive feelings about this drug, stating he is 'loving every second of it'.
#46–Chris Masterjohn, Ph.D.: Pathways to health and disease (NAD, sirtuins, methylation, choline...
Peter Attia MD
An immunosuppressant and anti-aging drug that works by inhibiting mTOR, a central nutrient sensor.
#112 – Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it
Peter Attia MD
A molecule discovered on Easter Island derived from soil bacterium, found to extend life by turning the same control knob as caloric restriction, inhibiting mTOR.
Dr. Peter Attia — Longevity Drugs, Alzheimer's Disease, and More
Tim Ferriss
A naturally occurring anti-fungal agent discovered on Easter Island, later found to have anti-proliferative properties and approved for organ transplantation. It has shown staggering lifespan improvement in animal studies and is being explored for longevity in humans.
The Life-Extension Episode With Dr. Matt Kaeberlein | The Tim Ferriss Show
Tim Ferriss
A drug being tested in the Dog Aging Project's clinical trial to slow and potentially reverse aspects of biological aging. It is known to reduce age-related sterile inflammation and reboot the immune system.
#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the ITP
Peter Attia MD
An mTOR inhibitor that has shown consistent and significant lifespan extension in ITP mice, even when started in middle age, with a stronger effect often seen in females due to higher blood levels.
#103 – Looking back on the first 99 episodes: Strong Convictions, Loosely Held
Peter Attia MD
A drug Peter Atia has been increasingly interested in for many years, for its potential longevity benefits, noting a turning point with a 2014 study on its effect on immune system vaccination response.
#37 – Zubin Damania, M.D.: Revolutionizing healthcare one hilariously inspiring video at a time
Peter Attia MD
An immunosuppressant drug (used in transplant rejection) discussed for its potential to extend lifespan and healthspan by inhibiting mTOR, with less fear of side effects at lower doses than ciprofloxacin.
#35 – Nir Barzilai, M.D.: How to tame aging
Peter Attia MD
An immunosuppressant and anti-aging drug that causes insulin resistance but extends lifespan in rodents, mentioned as an alternative anti-aging agent to Metformin.
Vitalik Buterin — Creator of Ethereum feat. Naval Ravikant
Tim Ferriss
A pharmaceutical drug, mentioned in the context of life extension and aging research, but Vitalik Buterin does not take it.
#70–David Sinclair, PhD: How cellular reprogramming could slow our aging clock, & the latest on NAD
Peter Attia MD
A drug discussed for its potential in extending lifespan in mice by around 30%, but its optimal pulsatile dosing in humans is still unclear, and it may interfere with muscle growth from exercise.
Exercise, Nutrition, Hormones for Vitality & Longevity | Dr. Peter Attia
Andrew Huberman
A geroprotective molecule with impressive animal literature showing preservation and extension of ovarian life in mouse models; human clinical trials are sought.
#66 – Vamsi Mootha, MD: Aging, T2D, cancer, dementia, Parkinson’s—do all roads lead to mitochondria?
Peter Attia MD
A drug with broad longevity benefits across many species, despite the complexity of biological systems.
#10 – Matt Kaeberlein, Ph.D.: rapamycin and dogs — living longer, healthier & turning back the clock
Peter Attia MD
A drug known to extend lifespan and slow aging, primarily by inhibiting the mTOR pathway, extensively discussed in the podcast.