Rapamycin

David Sinclair: Extending the Human Lifespan Beyond 100 Years | Lex Fridman Podcast #189

Lex Fridman

A drug that some people are experimenting with to counteract the effects of meat on long-term health by inhibiting the mTOR pathway, potentially extending lifespan.

Dr. Andrew Huberman — A Neurobiologist on Sleep, Performance, and Anxiety | The Tim Ferriss Show

Tim Ferriss

A drug mentioned in the context of canine research and longevity by Tim Ferriss.

#02 – Rhonda Patrick, Ph.D.: paradox of IGF-1, ketogenic diets and genetics, benefits of sauna, NAD+

Peter Attia MD

A drug known for its lifespan-extending effects across various organisms and its impact on senescent cells, discussed in the context of optimizing dosage and frequency for longevity.

Dr. Peter Attia, MD — Fasting, Metformin, Athletic Performance, and More | The Tim Ferriss Show

Tim Ferriss

A drug named after Rapa Nui, which they may discuss in relation to longevity.

Q&A With Tim — On Wealth, Legacy, Grief, Lyme Disease, and More | The Tim Ferriss Show

Tim Ferriss

A drug of interest to Tim Ferriss for longevity purposes, though challenging to determine human dosage.

E26: State of Venture Capital, plus fan questions on longevity, decentralization & quantum computing

All-In Podcast

Mentioned as a compound that can mimic fasting on a cellular level for longevity.

"Anti-Aging" Drugs — NAD, metformin, & rapamycin | The Peter Attia Drive Podcast (Ep 207, AMA 35)

Peter Attia MD

A geroprotective molecule discussed as a primary topic.

How to Ask Better Questions, Take Better Risks, and More! | The Tim Ferriss Show (Podcast)

Tim Ferriss

A drug that Tim Ferriss does not currently use but might incorporate in the future for longevity/autophagy protocols.

357 ‒ A new era of longevity science: models of aging, rapamycin trials, biological clocks, & more

Peter Attia MD

Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis

FoundMyFitness

A drug that blocks the mTOR pathway, discussed for its potential anti-aging effects but also associated with negative side effects like hyperglycemia and testicular degeneration.

Supplements for Longevity & Their Efficacy | Dr. Peter Attia

Andrew Huberman

A medication that targets mTOR, taken by Peter Attia for its geroprotective effects, demonstrating life extension in model organisms.

How to Exercise & Eat for Optimal Health & Longevity | Dr. Gabrielle Lyon

Andrew Huberman

A drug that inhibits mTOR, being explored by some as a way to extend lifespan, but poses a contradiction with resistance training which stimulates mTOR.

222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D.

Peter Attia MD

A drug frequently discussed for its potential geroprotective effects, working as an mTOR inhibitor. Its dosing and timing are still complex even in controlled settings.

216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.

Peter Attia MD

A medication Peter Attia takes, acknowledging it has good but imperfect evidence, contrasting with his reluctance to take NAD+ precursors due to lack of compelling human data.

205 - Energy balance, nutrition, & building muscle | Layne Norton, Ph.D. (Pt.2)

Peter Attia MD

An mTOR inhibitor, used as a cancer treatment drug, but not necessarily a good idea for cancer prevention due to potential side effects and its complex action on mTOR complex 1 and 2.

202 - Peter on nutrition, disease prevention, and more — looking back on the last 100 episodes

Peter Attia MD

A drug that will be discussed in a future AMA episode with Matt Kaeberlein regarding its role in longevity alongside Metformin and NAD+ precursors.

204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D.

Peter Attia MD

A well-known gerotherapeutic agent, often compared with metformin, with strong evidence for longevity extension in animal models, particularly through the ITP studies.

Outlive: The Science and Art of Longevity — Dr. Peter Attia

Tim Ferriss

Mentioned as a drug that can be important for longevity, alongside APO B control and metformin.

Dr. Rhonda Patrick Returns | The Tim Ferriss Show (Podcast)

Tim Ferriss

A compound shown to affect lifespan in animals, mentioned in comparison to Metformin.

#500! KevKev TimTim TalkTalk on Dragon Slaying, Lessons Learned, Viagra, and Assorted Nonsense

Tim Ferriss

A drug sometimes considered for longevity, which Tim Ferriss does not currently take but might consider in the future.

Intermittent Fasting to Improve Health, Cognition & Longevity | Dr. Satchin Panda

Andrew Huberman

A drug that reduces 'mTOR activation,' which also mimics aspects of the fasting state and can extend lifespan in mice.

Dr. Arthur De Vany Interview | The Tim Ferriss Show (Podcast)

Tim Ferriss

An immune-suppressant drug that shuts down mTOR; Art De Vany advises against its chronic use due to potential negative effects on immunity and growth.