How Cannabis Impacts Health & the Potential Risks | Dr. Matthew Hill

Host of the Huberman Lab podcast and a professor of Neurobiology and Ophthalmology at Stanford School of Medicine.

Guest on the podcast and a professor of Cell Biology and Anatomy at the University of Calgary, whose lab studies cannabis effects.

Colleague of Dr. Leah Mayo, involved in trials with FAAH inhibitors during her post-doctoral work in Sweden.

A researcher in California, potentially at UCLA, who conducted long-term studies on cannabis smokers and found no clear association with lung cancer.

A researcher in Colorado who, along with Kent Hutchinson and Cinnamon Bidwell, developed the 'Cannavan' for real-world cannabis research.

A researcher at Washington State University who pioneered vape chambers in rats to study cannabis self-administration.

From HHMI and UCSF, previously a guest on the Huberman Lab podcast, who discussed neurons in the hypothalamus.

Now at Northwestern, previously at Vanderbilt, who conducted studies on rodents demonstrating that reductions in endocannabinoid function produce anxiety, reversible by THC.

Scientist who isolated and discovered THC in 1964 and later isolated anandamide, considered the 'grandfather of the cannabinoid field'.

European researcher who created genetic lines of mice with CB1 receptor deletions from specific neuron types.

European researcher who created genetic lines of mice and conducted studies to understand how CB1 receptors influence anxiety by their location on excitatory or inhibitory neurons.

A colleague of Dr. Hill in Calgary who worked with Marcus Heilig in Sweden on FAAH inhibitor trials, and later on PTSD trials.

A researcher in Colorado who, along with Angela Bryan and Cinnamon Bidwell, pioneered the mobile 'Cannavan' to study cannabis use in ecological settings.

A researcher in Colorado who, along with Kent Hutchinson and Angela Bryan, introduced the 'Cannavan' to study cannabis use in natural environments.

A New York Times reporter who famously had an adverse experience with a high-dose cannabis edible in Colorado, highlighting unpredictable dosing.

Highly volatile compounds found in cannabis and many other plants that contribute to smell and flavor, and may influence psychoactive effects.

The primary receptor in the brain and body that THC acts upon, responsible for most psychoactive and behavioral effects of cannabis.

The theory that various molecules in cannabis (cannabinoids, terpenes) interact to produce different effects than THC alone.

A receptor mostly found on immune cells, not widely expressed in the brain, primarily involved in regulating inflammatory processes.

The second primary endogenous cannabinoid, which has a lower affinity but higher efficacy at the CB1 receptor than anandamide, and is thought to be involved in rapid, on-demand synaptic regulation (phasic signaling).

One of the primary endogenous cannabinoids, named after the Sanskrit word for 'Bliss,' often described as having high affinity but low efficacy at the CB1 receptor and may act as a tonic regulator.

Molecules naturally produced by the body (like anandamide and 2-AG) that act on cannabinoid receptors, primarily to maintain homeostasis.

A cannabinoid that is structurally similar to THC but is not intoxicating, though some consider it psychoactive due to effects on anxiety or mood.

The US federal agency that funds cannabis research in humans and historically sourced all cannabis for studies from a farm in Mississippi.

An organization where Dr. Hill is an executive director, focused on creating agnostic, science-based educational platforms about cannabis.

Academic institution where Dr. Matthew Hill is a professor.

A Canadian organization that developed 'lower-risk cannabis use guidelines' to promote harm reduction.

Pharmaceutical company that developed a FAAH inhibitor and tested it for social anxiety disorder, showing moderate efficacy.

Pharmaceutical company that developed the first FAAH inhibitor for pain, though initial trials were not successful.

A synthetic form of THC available in Canada and used in a Canadian military study for PTSD, showing effectiveness in suppressing nightmares.

A synthetic form of THC accessible in the United States, which has shown some anti-anxiety properties in older studies.

The main cannabinoid molecule in cannabis responsible for its intoxicating and psychoactive effects.

Pharmaceutical drugs (like those developed by Pfizer and Johnson & Johnson) that block the enzyme Fatty Acid Amide Hydrolase (FAAH) which breaks down anandamide, leading to elevated anandamide levels without intoxication.