Melatonin
Hormone signaling light exposure; endogenous production varies with seasons; supplements are often supra-physiological and require caution, especially during pregnancy.
Research
Common Themes
Videos Mentioning Melatonin
Optimize & Control Your Brain Chemistry to Improve Health & Performance | Huberman Lab Podcast #80
Andrew Huberman
A hormone important for sleep; its production can be negatively impacted by bright light exposure between 10 PM and 4 AM.
Whitney Cummings Interview (Full Episode) | The Tim Ferriss Show (Podcast)
Tim Ferriss
A chewable supplement used by Tim Ferriss for resetting his clock when traveling.
How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett
Andrew Huberman
A sleep supplement whose daily use is arguable and depends on the situation.
Dr. Andrew Huberman — A Neurobiologist on Sleep, Performance, and Anxiety | The Tim Ferriss Show
Tim Ferriss
A sleep hormone generally not recommended by Dr. Huberman due to its broad effects on the reproductive axis and the super physiological doses commonly found in supplements.
How to Control Your Metabolism by Thyroid & Growth Hormone
Andrew Huberman
A hormone often supplemented for sleep; however, low doses (around 500 micrograms) might be advantageous in shifting early night sleep towards more slow-wave deep sleep and improving growth hormone release, as higher doses can suppress reproductive hormones and puberty.
How to Secure Financial Freedom and Maximize Productivity | The Tim Ferriss Show (Podcast)
Tim Ferriss
A supplement (typically 3mg tablets) used for sleep support, with fans including Art Devaney and Dominic D'Agostino.
Dr. Peter Attia, MD — Fasting, Metformin, Athletic Performance, and More | The Tim Ferriss Show
Tim Ferriss
Sleep supplement Peter Attia reserves for jetlag or specific fasting situations, preferring not to rely on it for regular sleep.
The Science of Emotions & Relationships
Andrew Huberman
A hormone often used as a sleep supplement, which in some cases can prime the system for slightly increased oxytocin release, though Huberman typically pushes back against its use for sleep due to side effects.
Tools for Managing Stress & Anxiety
Andrew Huberman
A hormone-like supplement secreted from the pineal gland, often used to help fall asleep, but typically supplemented at very high, super-physiological levels, with potential negative effects on the reproductive axis and possibility of suppressing adrenal output.
How to Defeat Jet Lag, Shift Work & Sleeplessness
Andrew Huberman
A hormone released from the pineal gland that induces sleepiness but does not help stay asleep. Its supplementation, especially in high doses, may have detrimental effects on hormone systems like GnRH, LH, testosterone, and estrogen, particularly in developing children.
Using Science to Optimize Sleep, Learning & Metabolism
Andrew Huberman
A hormone inhibited by light, whose signal duration communicates external day length to the body, influencing mood, reproduction, and metabolism. Increased by cold.
A.J. Jacobs — 10 Strategies to Be Happier Through Gratitude | The Tim Ferriss Show (Podcast)
Tim Ferriss
A sleep aid mentioned as a remedy that failed before the speaker found success with CBD oil.
Nick Kokonas Interview | The Tim Ferriss Show (Podcast)
Tim Ferriss
A common sleep aid mentioned as having failed for Tim Ferriss before he tried CBD oil.
Hamilton Morris — Psychedelics, Smart Drugs, and More
Tim Ferriss
A hormone from which 5-MeO-DMT can be synthesized much more efficiently and cheaply than extracting from toad venom.
Dr. Satchin Panda on Time-Restricted Feeding and Its Effects on Obesity, Muscle Mass & Heart Health
FoundMyFitness
Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation | Dr. Casey Means
Andrew Huberman
Hormone secreted as sleep approaches, which may transiently impair insulin sensitivity, leading to poorer glucose absorption from late-night meals.
Dr. Matt Walker: Protocols to Improve Your Sleep | Huberman Lab Guest Series
Andrew Huberman
A hormone released in darkness that helps time the onset of sleep. Its release is inhibited by bright light.
Q&A: Hormonal Contraceptives, Rates of Weight Loss/Gain, Timeline of Training Adaptations (Ep 9)
Stronger By Science
Mentioned as one of the main triggers for growth hormone release, with production decreasing as people age.
202 - Peter on nutrition, disease prevention, and more — looking back on the last 100 episodes
Peter Attia MD
A sleep aid that, unlike phenibut, requires limited and infrequent use due to potential concerns.
Dom D'Agostino Returns (Full Episode) | The Tim Ferriss Show (Podcast)
Tim Ferriss
Part of a sleep cocktail and used when crossing time zones, with typical daily doses of 1-5 mg and up to 10 mg for jet lag.
Will MacAskill Interview (Full Episode) | The Tim Ferriss Show (Podcast)
Tim Ferriss
A hormone often used to reset sleep cycles, particularly after travel or for sleep regulation.
Rick Rubin Interview (Full Episode) | The Tim Ferriss Show (Podcast)
Tim Ferriss
A supplement used for resetting the body clock when traveling, offered by Onnit.
Arnold Schwarzenegger — On Psychological Warfare
Tim Ferriss
A supplement used by Tim Ferriss for resetting his clock when traveling.
Dr. Andy Galpin: Optimal Nutrition & Supplementation for Fitness | Huberman Lab Guest Series
Andrew Huberman
A sleep aid where quality and dosage are highly variable in commercially available products, with some containing significantly more active ingredient than labeled. This inconsistency can lead to adverse effects and disrupt natural sleep cycles.