Ketamine

Safi Bahcall — On Hypnosis, Conquering Insomnia, Incentives, and More | The Tim Ferriss Show

Tim Ferriss

A compound explored for rapid effectiveness in treating acute suicidal ideation and depression, with a short half-life but long-lasting effects.

Nick Norris — Navy SEAL and Athlete on Training | The Tim Ferriss Show (Podcast)

Tim Ferriss

A powerful tool for treatment-resistant depression and suicidal ideation, which is legal and available in clinics, also recently approved for nasal administration.

Lisa Feldman Barrett: Counterintuitive Ideas About How the Brain Works | Lex Fridman Podcast #129

Lex Fridman

A substance mentioned in the context of completely removing 'tethers' from the external world during its effects.

Psychedelics — Microdosing, Mind Enhancing Methods, and More | The Tim Ferriss Show (Podcast)

Tim Ferriss

A drug recently approved for depression treatment, known for immediate antidepressant effects that last 1-3 weeks.

Understand and Use Dreams to Learn and Forget

Andrew Huberman

A dissociative anesthetic used clinically for trauma treatment by preventing the attachment of intense emotions to experiences.

Dustin Yellin on Making Art, Weaving Madness, and Forging Your Own Path | The Tim Ferriss Show

Tim Ferriss

A dissociative anesthetic and hallucinogen administered by the physicist to Dustin Yellin during his 'pure consciousness state' experiments.

Tim Ferriss — My Healing Journey After Childhood Abuse

Tim Ferriss

A dissociative anesthetic mentioned as a very effective acute treatment for stopping loops of suicidal ideation, available intravenously or intramuscularly in clinics, and on the WHO essential medicines list.

The Psychedelic News Hour - New Breakthroughs, Treatment of Trauma, and More | The Tim Ferriss Show

Tim Ferriss

A dissociative anesthetic used in assisted psychotherapy, with its own protocol (KET-AP). Discussed as a 'gateway drug' for psychedelic experiences.

The Frontiers of Psychedelics — Michael Pollan

Tim Ferriss

An anesthetic that also has psychedelic effects at sufficient doses. It was recently approved and is considered one of the WHO's essential medicines. It's being used in legal clinics as a therapeutic option.

Thinking Differently About Addiction and Mental Health — Dr. Nora Volkow

Tim Ferriss

A dissociative anesthetic drug also used for its antidepressant properties. While not a classical psychedelic, its successful use in treating depression opened doors for research into other novel therapeutics like psychedelics and showed value in chronic pain.

Rethinking Psychedelics, Octopuses on MDMA, and The Master Key of Metaplasticity | Dr. Gül Dölen

Tim Ferriss

A psychedelic drug that reopens critical periods, also discussed in relation to NMDA receptors and memory impairment.

Jonathan Reisman: The Human Body - From Sex & Sperm to Hands & Heart | Lex Fridman Podcast #297

Lex Fridman

Drug used for pain control in battlefield medicine, highlighted as an advancement stemming from war.

Rhonda Patrick, Ph.D. — Protocols for Fasting, Lowering Dementia Risk, Reversing Heart Aging, & More

Tim Ferriss

How to Thrive in an AI World, Tips for Life’s Darkest Hours, & The Art of Sabbaticals (4K)

Tim Ferriss

A very interesting tool for acute suicidal ideation and risk of self-harm, often administered intravenously or intramuscularly as a pattern interrupt, but with addiction potential.

2024 New Year’s Resolutions, AI Upheavel, & Much More! | The Random Show (4K)

Tim Ferriss

A dissociative anesthetic used for PTSD, severe depression, and anxiety, capable of rewiring neural pathways and providing relief from psychological burdens. Its recreational use is dangerous, especially with water.

LIVE EVENT Q&A: Dr. Andrew Huberman at the ICC Sydney Theatre

Andrew Huberman

Discussed as potentially addictive and as an NMDA receptor blocker that can induce neuroplasticity, but with a caution against maladaptive plasticity.

Bee AI: The Wearable Ambient Agent

Latent Space

Not explicitly mentioned, but discussed in the context of mental health treatments.

A $1M Bitcoin Bet, Preventing Hangovers, AI Companions, Affordable Luxuries, Hi-Fi Audio, and More!

Tim Ferriss

A dissociative anesthetic and recreational drug that some people use, with a warning about it being mixed with fentanyl.

Tools to Reduce & Manage Pain | Dr. Sean Mackey

Andrew Huberman

A therapeutic drug similar to PCP, widely used therapeutically for various conditions though typically a Schedule III drug.

Erik Vance (Full Episode) | The Tim Ferriss Show (Podcast)

Tim Ferriss

A dissociative anesthetic used to tranquilize animals like porcupines during field research; also mentioned as being fascinating to a recovering addict.

220 ‒ Ketamine: Benefits, risks, and promising therapeutic potential | Celia Morgan, Ph.D.

Peter Attia MD

A dissociative anesthetic synthesized in the 1960s, initially as an anesthetic and analgesic, now gaining interest for its rapid antidepressant and anti-addiction effects, primarily working on the NMDA receptor. It has dose-dependent effects ranging from mild dissociation to complete anesthesia and hallucinations.

How to Improve Memory & Focus Using Science Protocols | Dr. Charan Ranganath

Andrew Huberman

A dissociative anesthetic mentioned for its interesting plasticity effects and the dissociative element it produces, distinct from psychedelics.

Dr. Andrew Huberman — The Foundations of Physical and Mental Performance

Tim Ferriss

A dissociative anesthetic with antidepressant effects, included in discussions about psychedelic therapies, but not strictly a classic psychedelic.

Karl Deisseroth: Depression, Schizophrenia, and Psychiatry | Lex Fridman Podcast #274

Lex Fridman

An agent that, along with PCP, was used in dissociation experiments to understand how altered rhythms in the retrosplenial cortex can cause separation of the sense of self from the body.