SSRIs
Selective serotonin reuptake inhibitors, a class of antidepressant drugs, linked to a 75% increased risk of dementia in a meta-analysis of five studies.
Research
Common Themes
Videos Mentioning SSRIs

LIVE EVENT Q&A: Dr. Andrew Huberman Question & Answer in Chicago, IL
Andrew Huberman
Selective Serotonin Reuptake Inhibitors, commonly used antidepressants. The video suggests their efficacy might stem from promoting neuroplasticity rather than directly addressing serotonin deficiency.

Brain Experts WARNING: Watch This Before Using ChatGPT Again! (Shocking New Discovery)
The Diary Of A CEO
Selective serotonin reuptake inhibitors, a class of antidepressant drugs, linked to a 75% increased risk of dementia in a meta-analysis of five studies.

LIVE EVENT Q&A: Dr. Andrew Huberman Question & Answer in Toronto, ON
Andrew Huberman
Selective serotonin reuptake inhibitors, discussed in the context of depression treatment and their relation to serotonin levels.

Mental Health Toolkit: Tools to Bolster Your Mood & Mental Health
Andrew Huberman
A class of prescription drugs that target specific neuromodulator systems to open neuroplasticity, often combined with talk therapy.

How to Understand Emotions | Dr. Lisa Feldman Barrett
Andrew Huberman
Antidepressant medications discussed as potentially 'juicing' the system but eventually leading to metabolic adjustments and potential long-term depletion of mood-enhancing neural systems.

Life, Death & the Neuroscience of Your Unique Experience | Dr. David Linden
Andrew Huberman
A class of antidepressant drugs that benefit only about a third of depressed people, with limited or no benefit for others, possibly due to depression being multiple biological disorders or inflammation acting as a barrier to their efficacy.

164 - Diagnosing, preventing, & treating Alzheimer’s disease, & life lessons from dementia patients
Peter Attia MD
A class of antidepressants frequently prescribed for anxiety and depression in dementia patients due to their effectiveness and good tolerability, generally not increasing fall risk.

The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast
Andrew Huberman
A class of antidepressant drugs like Prozac and Zoloft, which increase serotonin but do not produce the same pro-social effects as MDMA and can block them if taken concurrently.

Kelsi Sheren: War, Artillery, PTSD, and Love | Lex Fridman Podcast #230
Lex Fridman
A class of antidepressants, mentioned as medications that need to be weaned off before psychedelic treatments like ayahuasca.

The Science of Psychedelics for Mental Health | Dr. Robin Carhart-Harris
Andrew Huberman
A class of antidepressants that act by indirectly increasing serotonin levels, compared to direct 5-HT2A agonists. Used as a reference for traditional pharmacotherapy.

Developing a Rational Approach to Supplementation for Health & Performance | Huberman Lab Podcast
Andrew Huberman
Pharmaceuticals used to treat depression and OCD, known to sometimes cause reduced libido, which Maca root can help to alleviate.

Nicotine’s Effects on the Brain & Body & How to Quit Smoking or Vaping
Andrew Huberman
A class of antidepressants that some people experience negative side effects from, leading to alternatives like Bupropion.

Optimize & Control Your Brain Chemistry to Improve Health & Performance | Huberman Lab Podcast #80
Andrew Huberman
Prescription drugs that increase serotonin levels in the brain and body for treating depression, but can have side effects if dosages are too high.

E100: Reflecting on the first 100 shows, fan questions, nuclear threat, markets, Amazon & more
All-In Podcast
Mentioned as part of a joke about David Friedberg's mental state, with his psychiatrist working on his 'cocktail'.

253 ‒ Hormone replacement therapy and the Women’s Health Initiative: re-examining the results
Peter Attia MD
Selective Serotonin Reuptake Inhibitors, a class of antidepressant medications that can be used as non-hormonal treatments for hot flashes.

Safi Bahcall — On Hypnosis, Conquering Insomnia, Incentives, and More | The Tim Ferriss Show
Tim Ferriss
A class of pharmaceutical drugs used for depression, with varied efficacy among individuals.

Psychedelics — Microdosing, Mind Enhancing Methods, and More | The Tim Ferriss Show (Podcast)
Tim Ferriss
Selective Serotonin Reuptake Inhibitors, a class of antidepressants.

All Things Sleep (Weight Gain, Alzheimer’s Disease, Caffeine, and More) — Dr. Matthew Walker
Tim Ferriss
A class of antidepressant medications. Their use can increase sensitivity to caffeine and decrease its clearance, potentially disrupting sleep. Also, combining SSRIs with certain psychedelics like Ayahuasca can be dangerous.

2023 Resolutions and New Tools, Booze and Ethanol Alternatives, The “Yearly Delete,” and Much More
Tim Ferriss
A class of antidepressants. Mentioned as a concurrent medication that can cause severe side effects like serotonin syndrome when combined with Ayahuasca.

The Science of Love, Desire and Attachment
Andrew Huberman
Antidepressants like Prozac and Zoloft, which can sometimes lead to sexual dysfunction, an effect that Maca supplementation has been shown to offset.

The Possibilities of Mind-Altering Compounds | Dr. Suresh Muthukumaraswamy | The Tim Ferriss Show
Tim Ferriss
Selective serotonin reuptake inhibitors, a class of conventional antidepressants that typically take 6-8 weeks to show effects, contrasting with the rapid action of ketamine.

A Few Thoughts About RFK Jr. (Episode #325)
Sam Harris
Cited by RFK Jr. as a cause for mass shootings, a claim the speaker dismisses as 'wacky'.

Unlearn Negative Thoughts & Behaviors Patterns | Dr. Alok Kanojia (Healthy Gamer)
Andrew Huberman
Selective serotonin reuptake inhibitors, mentioned in the context of treatment for depression and compared to exercise effectiveness.

Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson
Andrew Huberman
A class of traditional antidepressants like Prozac, which microdosing psilocybin is sometimes claimed to be a 'better version' of. They augment extracellular serotonin to reduce depressive symptoms.