MDMA

Predicting Reality: A Conversation with Andy Clark (Episode #322)

Sam Harris

Andy Clark has experience with MDMA, which is discussed in relation to emotion due to its non-classic psychedelic nature.

Using Meditation to Focus, View Consciousness & Expand Your Mind | Dr. Sam Harris

Andrew Huberman

A drug that Sam Harris and Andrew Huberman have personally experienced, described as a 'gateway drug' for Harris into exploring the mind, and for Huberman, a tool for confronting scary conscious issues and facilitating a transition from animal to human research.

Q&A with Tim Ferriss — Habits, Sleep, Journaling, Psychedelics, HRV Training, and More

Tim Ferriss

Mentioned in the context of fundraising for its therapeutic use in medicine.

Constructing Self and World: A Conversation with Shamil Chandaria (Episode #320)

Sam Harris

Mentioned by Sam Harris as a substance he has recently had an experience with, related to the discussion on psychedelics.

Science of Social Bonding in Family, Friendship & Romantic Love

Andrew Huberman

A substance that causes massive increases in oxytocin release, being explored in clinical trials for trauma, depression, eating disorders, and reestablishing fractured bonds.

Hamilton Morris on Iboga, 5-MeO-DMT, the Power of Ritual, New Frontiers in Psychedelics, and More

Tim Ferriss

A compound discussed in the context of it being placed in Schedule I in the 1980s despite its therapeutic potential and non-hallucinogenic properties, leading to Shulgin's radicalization.

Knowing The Mind: A Conversation with Steven Laureys (Episode: #227)

Sam Harris

A psychedelic drug, also known as ecstasy, which precipitated Steven Laureys' interest in meditation.

#34 – Sam Harris, Ph.D.: The transformative power of mindfulness

Peter Attia MD

A substance Sam Harris used at age 18 that led to a breakthrough experience of empathy and loss of self-concern, which he describes in his book 'Waking Up'.

LIVE EVENT Q&A: Dr. Andrew Huberman Question & Answer in New York, NY

Andrew Huberman

Mentioned in the context of clinical trials for therapeutic uses, with much knowledge coming from the LDS community.

Erasing Fears & Traumas Based on the Modern Neuroscience of Fear

Andrew Huberman

A powerful synthetic drug that, in therapeutic settings, leads to massive increases in dopamine, serotonin, and oxytocin simultaneously, inducing feelings of euphoria, connection, and safety, making it a promising treatment for trauma.

Researching Psilocybin's Effects on Depression - Dr. Rosalind Watts

Y Combinator

Mentioned in the context of David Nutt's scientific report which stated it was less dangerous than horse-riding, leading to his dismissal.

Cutting-Edge Science for Eye Health — Dr. Jeffrey Goldberg

Tim Ferriss

#25 – Scott Harrison: transformation, finding meaning, and taking on the global water crisis

Peter Attia MD

An illicit drug Scott Harrison used, including during his New Year's Eve party epiphany.

LIVE EVENT Q&A: Dr. Andrew Huberman Question & Answer in Los Angeles, CA

Andrew Huberman

Mentioned in the context of psychedelics, noting its potential to alter the chemical landscape and serve as attractors during therapeutic sessions if not guided.

Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson

Andrew Huberman

A compound called an 'entactogen,' primarily acting through serotonin release, and structurally related to amphetamine. It is being developed for PTSD treatment due to its ability to facilitate emotional connection.

Healthy Eating & Eating Disorders - Anorexia, Bulimia, Binging

Andrew Huberman

A psychoactive drug that increases dopamine and serotonin, being explored in clinical trials at Johns Hopkins for its potential to help rewire the brain for conditions like major depression and eating disorders.

Cindy Eckert (formerly Whitehead) Interview | The Tim Ferriss Show

Tim Ferriss

A substance with 'breakthrough therapy designation' for PTSD, currently undergoing trials with Astonishing results, catching Tim Ferriss's interest in regulatory processes.

Jordan Peterson on Rules for Life, Psychedelics, The Bible, and More

Tim Ferriss

A substance being studied in conjunction with psychotherapy, mentioned in the context of phase three trials and responsible use.

Joscha Bach: Nature of Reality, Dreams, and Consciousness | Lex Fridman Podcast #212

Lex Fridman

A psychedelic substance discussed for its potential to help with PTSD in clinical settings, but also its neurotoxicity and hepatotoxicity risks.

Understanding & Conquering Depression

Andrew Huberman

Primarily explored for treating trauma, with some ongoing trials for depression. Discussion of MDMA is deferred to a future podcast episode.

Brian Muraresku: The Secret History of Psychedelics | Lex Fridman Podcast #211

Lex Fridman

A compound (not technically a psychedelic but often discussed alongside them) recognized for its therapeutic potential in various conditions like PTSD, with projections for legal, FDA-regulated use soon.

Understanding & Treating Addiction | Dr. Anna Lembke

Andrew Huberman

Also known as ecstasy, a drug being researched in clinical trials for trauma and addiction treatment, often discussed in relation to serotonin and dopamine release.

Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan Williams

Andrew Huberman

An experimental drug with anti-trauma properties that preliminary data show promise for the treatment of depression and other mood disorders, used in combination with TMS by Dr. Williams's lab.

#81 – Debra Kimless, M.D. & Steve Goldner, J.D.: Cannabis – the latest science on CBD & THC

Peter Attia MD

A Schedule I controlled substance currently in Phase 3 studies by MAPS, showing how research on federally controlled substances can progress with dedicated effort and funding.