FGF21
A protein secreted in response to a low protein diet, implicated in liver metabolism and inhibition of mTOR, and thought to be required for lifespan extension from protein restriction in mice.
Videos Mentioning FGF21

#48–Matt Walker, Ph.D., on Sleep (Part 2 of 3): Heart disease, cancer, causes of sleep disruption...
Peter Attia MD
A hormone mentioned as potentially inhibiting FSH in women under fasted states, with a possible link to ketogenic diets. Its role in men's reproductive fitness under fasting appears different.

AMA #3: supplements, women’s health, patient care, and more (EP.26) | The Peter Attia Drive
Peter Attia MD
Fibroblast growth factor 21. Changes in its levels showed differences in male and female brain responses, particularly in calorie-restricted, ketotic states, affecting FSH and LH in women.

222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D.
Peter Attia MD
A protein secreted in response to a low protein diet, implicated in liver metabolism and inhibition of mTOR, and thought to be required for lifespan extension from protein restriction in mice.