PI3-kinase

Concept

A pathway which, when mutated, can make cells take advantage of hyperinsulinemia.

Mentioned in 3 videos

Videos Mentioning PI3-kinase

#140 - Gerald Shulman, MD, PhD: Insulin resistance—molecular mechanisms and clinical implications

#140 - Gerald Shulman, MD, PhD: Insulin resistance—molecular mechanisms and clinical implications

Peter Attia MD

A crucial enzyme in the insulin signaling pathway, activated downstream of IRS1, which is required for Glut4 translocation.

#187 - The Warburg Effect: Otto Warburg’s Cancer Metabolism Theory with Sam Apple

#187 - The Warburg Effect: Otto Warburg’s Cancer Metabolism Theory with Sam Apple

Peter Attia MD

A pathway which, when mutated, can make cells take advantage of hyperinsulinemia.

#123–Joan Mannick & Nir Barzilai: Rapamycin and metformin—longevity, immune enhancement, & COVID-19

#123–Joan Mannick & Nir Barzilai: Rapamycin and metformin—longevity, immune enhancement, & COVID-19

Peter Attia MD

Phosphoinositide 3-kinase, an enzyme whose inhibitory properties are also present in RTB101 at high concentrations, though its primary action is mTORC1 inhibition at physiological doses.