Desmosterol

Concept

A penultimate sterol in the cholesterol synthesis pathway, primarily used by astrocytes and steroidogenic tissue. Serum desmosterol levels are being investigated as a biomarker for brain cholesterol synthesis and Alzheimer's risk.

Mentioned in 4 videos

Videos Mentioning Desmosterol

#134 - James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise

#134 - James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise

Peter Attia MD

A marker of cholesterol synthesis, monitored closely in Dr. Attia's practice.

#23–Tom Dayspring Part IV of V: statins, Zetia, PCSK9 inhibitors, niacin, cholesterol & the brain

#23–Tom Dayspring Part IV of V: statins, Zetia, PCSK9 inhibitors, niacin, cholesterol & the brain

Peter Attia MD

A direct precursor to cholesterol in the Bloch pathway, which predominates in the brain. Serum desmosterol levels can serve as a biomarker for brain cholesterol synthesis, and its suppression by statins is a concern for cognitive health in susceptible individuals.

#21 – Tom Dayspring, M.D., FACP, FNLA – Part II of V: Lipid metrics and cholesterol regulation

#21 – Tom Dayspring, M.D., FACP, FNLA – Part II of V: Lipid metrics and cholesterol regulation

Peter Attia MD

A precursor molecule in cholesterol synthesis, similar to cholesterol but with a double bond at carbon 24 in the tail. A deficiency in the enzyme that saturates this bond can lead to a severe genetic disorder.

334 - Cardiovascular disease, the number one killer: development, biomarkers, apoB, and more

334 - Cardiovascular disease, the number one killer: development, biomarkers, apoB, and more

Peter Attia MD

A penultimate sterol in the cholesterol synthesis pathway, primarily used by astrocytes and steroidogenic tissue. Serum desmosterol levels are being investigated as a biomarker for brain cholesterol synthesis and Alzheimer's risk.