Aldose reductase

Concept

The rate-limiting enzyme in the polyol pathway that converts glucose to sorbitol. It is normally low in the liver but can be induced by high glucose, high uric acid, and increased serum osmolality.

Mentioned in 2 videos

Videos Mentioning Aldose reductase

How Fructose Drives Metabolic Disease | Rick Johnson, M.D.

How Fructose Drives Metabolic Disease | Rick Johnson, M.D.

Peter Attia MD

The rate-limiting enzyme in the polyol pathway that converts glucose to sorbitol. It is normally low in the liver but can be induced by high glucose, high uric acid, and increased serum osmolality.

#87—Rick Johnson, MD: Fructose—the common link in hypertension, insulin resistance, T2D, & obesity?

#87—Rick Johnson, MD: Fructose—the common link in hypertension, insulin resistance, T2D, & obesity?

Peter Attia MD

An enzyme that converts glucose to fructose, induced by high glucose levels, especially in obese individuals or diabetics, leading to endogenous fructose production even on a fructose-free diet.